Penicillin G is a bactericidal, time-dependent β-lactam antibiotic with good activity against many Gram-positive organisms, though it is not effective against β-lactamase-producing Staphylococcus spp., α-Streptococcus spp., or Rhodococcus equi. It has limited efficacy against Gram-negative bacteria. Penicillin G distributes widely through the plasma but has low lipid solubility and does not penetrate abscesses or sites of tissue necrosis well. The active …

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